Fourth Generation High-Mass MALDI Detector Retrofit Systems

Introducing two choices for your high mass detection needs

A decade in development, CovalX is proud to announce our fourth generation in a series of High-Mass MALDI detection systems based on a unique conversion dynode technology. The CovalX HM4 and Pearl High-Mass systems enable unmatched detection of macromolecular ions into the MegaDalton range with nM sensitivity. The Pearl offers all the benefits in sensitivity and saturation you have come to trust from CovalX while keeping an emphasis on value. The HM4 system is the latest flagship reference for the detection of high molecular weight macromolecules. 


HM4 Flagship High Mass Detection System

The CovalX HM4 High Mass Detection retrofit systems incorporates every piece of technology possible for detection of high mass ions at the most sensitive levels. The Conversion Dynodes and Detection elements are specifically selected and all available features are included. Both positive and negative ion detection come standard, a large touchscreen with updated application including full control and monitoring of the detector system. Specifically designed for ultrahigh mass applications with detection to 2MDa and above.


Pearl High Mass Detection System

By making use of our years of knowledge and utilizing specially selected components CovalX's Pearl High Mass Detection System provides an order of magnitude better detection than any standard OEM detector available.  Through years of product development and selecting specific components it is possible to achieve superb sensitivity at a reasonable cost.  The CovalX Pearl provides access to all the CovalX applications up to MegaDalton mass range.









HM4 vs Pearl Comparison Chart



    All High-Mass systems are available for every standard MALDI ToF mass spectrometers:

  • Applied Biosystems: 5800, 4800 and all previous models.
  • Bruker: UltrafleXtreme, Autoflex Speed and all previous models.
  • Shimadzu Kratos: Axima series.


No Change in Manufacturer Warranties and Services:

Installing a CovalX HM4 High-Mass System on your MALDI ToF mass spectrometer does not change any of the warranties or service contracts you may have with Bruker, ABSciex or Shimadzu.

CovalX's HM4 are controlled wirelessly using the CovalX's Android application. To switch between High-Mass detection and standard detection or between positive and negative ion detection modes, simply press a button on the touch screen of your CovalX's Kindle controller.

CovalX HM4 High-Mass Systems does not change any of the previous features of your MALDI ToF instrument. After retrofit, the standard detector in the linear mode is not removed. The operator can choose between high mass detection and normal detection in few seconds simply by pressing a button on the touch screen of CovalX's Kindle controller.

TERN-1 Spectra
HM4 High-Mass MALDI ToF mass spectra of an intact virus capsid (8.5 µM). The singly charged pseudo-molecular ions of virus capsid TERN-1 is detected with MH+=2011 kDa.



With CovalX HM4 High-Mass Systems you can have access to the following applications:

For more information concerning HM4 High-Mass retrofit for your MALDI ToF instrument, please contact our Customer Support Centers.