MegaTOF MALDI Mass Spectrometer: A New MALDI Instrument by Shimadzu and CovalX
Shimadzu and CovalX have partnered to offer an integrated MALDI solution for ultrahigh mass applications. The MegaTOFTM has been developed by optimizing the integration of a high performance Shimadzu linear MALDI TOF mass spectrometer with CovalX high-mass system, allowing outstanding detection of macromolecules up to 1500 kDa. MegaTOFTM MALDI MS gives access to a broad range of applications, including direct analysis of protein-protein interactions such as complexes or biopharmaceutical aggregates. For these analyses, CovalX developed special cross-linking reagents and buffers for a fast and specific stabilization of protein interactions. The reagents contain ‘cocktails’ of cross-linkers with different spacer lengths able to covalently bind specific protein complexes with a high degree of efficiency. The specificity facilitates the stabilization of covalent protein complexes – even in contaminated or unpurified samples. The High-Mass MALDI applications are also available for the existing Shimadzu AXIMA MALDI (Assurance, Confidence, Performance) by retrofitting CovalX’s HM2 or HM2 TUVO high-mass system on these instruments.
MegaTOFTM MALDI Mass Spectrometer will be launched at the 58th ASMS conference in Salt Lake City, May 23-27th. The instrument will be exhibited during the conference at Shimadzu Hospitality Suite (253 A&B). For more information, you can meet our teams at the conferences (CovalX Booth 75; Shimadzu Booth 86).