CovalX HM4 High Mass Detection System

A decade in development, CovalX is proud to announce our fourth generation in a series of High-Mass MALDI detection systems based on a unique conversion dynode technology. The CovalX HM4 and Pearl High-Mass systems enable unmatched detection of macromolecular ions into the MegaDalton range with nM sensitivity. The Pearl offers all the benefits in sensitivity and saturation you have come to trust from CovalX while keeping an emphasis on value. The HM4 system is the latest flagship reference for the detection of high molecular weight macromolecules. 

The HM4 Flagship High Mass Detection System

The CovalX HM4 High Mass Detection retrofit systems incorporate every piece of technology possible for detection of high mass ions at the most sensitive levels. High Mass Detection

The Conversion Dynodes and Detection elements are specifically selected and all available features are included. Both positive and negative ion detection come standard. A large touchscreen with the updated application including full control and monitoring of the detector system. Specifically designed for ultrahigh mass applications with detection to 2MDa and above.


Fourth Generation High-Mass Detector Retrofit Systems Comparison
  Pearl HM4
Full compatibility with any MALDI Instrument (Shimadzu, Bruker, ABSciex)
Wireless Touchscreen Control
Automated switching between High-Mass & Standard Detection
Detection of macromolecules and protein complexes up to 1 MDa
Positive Ion Detection
Detection of macromolecules and protein complexes to 2 MDa and above  
Negative Ion Detection  

See more about Pearl here

All High-Mass systems are available for every standard MALDI ToF mass spectrometers:

  • Applied Biosystems: 5800, 4800 and all previous models.
  • Bruker: UltrafleXtreme, Autoflex Speed and all previous models.
  • Shimadzu Kratos: Axima series.

No Change in Manufacturer Warranties and Services:

Installing a CovalX HM4 High-Mass System on your MALDI ToF mass spectrometer does not change any of the warranties or service contracts you may have with Bruker, ABSciex or Shimadzu.
CovalX's HM4 are controlled wirelessly using the CovalX's Android application. To switch between High-Mass detection and standard detection or between positive and negative ion detection modes, simply press a button on the touchscreen of your CovalX's Kindle controller.
CovalX HM4 High-Mass Systems does not change any of the previous features of your MALDI ToF instrument. After the retrofit, the standard detector in the linear mode is not removed. The operator can choose between high mass detection and normal detection in a few seconds simply by pressing a button on the touch screen of CovalX's Kindle controller.


With CovalX HM4 High-Mass Systems you can have access to the following applications:

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