Inventors
Carolyn R. Bertozzi, Nicholas Till, Mariko Marimoto
Assignees
Leland Stanford Junior University
Abstract
Aspects of the present disclosure include bifunctional molecules. The bifunctional molecules comprise a first moiety comprising a CD206 ligand that binds CD206 on the surface of a cell and induces CD206-mediated endocytosis. The bifunctional molecules further comprise a second moiety that specifically binds a molecule on the surface of the cell or an extracellular molecule. In certain embodiments, the CD206 ligand comprises a monosaccharide, disaccharide, or trisaccharide comprising mannose, fucose, a sulfated glycan, or any combination thereof. In some instances, the cell is a tumor-associated macrophage (TAM) and the second moiety is an immune checkpoint molecule, e.g., SIRPα or other immune checkpoint molecule of interest. According to some embodiments, binding of the second moiety to the immune checkpoint molecule does not block activity of the immune checkpoint molecule. Also provided are methods of using the bifunctional molecules of the present disclosure, e.g., in therapy.