XL-MS and XRC comparison study for PD-1 and CTL-4

Three thereapeutic monoclonal antibody complexes were studied:
Ipilimumab/CTL-4
Nivolumab/PD-1
Nivolumab/PD-1

This study demonstrates strong correlation between the CovalX XL-MS method and existing X-ray cocrystal structure data for epitope mapping of three popular targets.

Poster presented at the recent PEGS Europe 2017 conference in Lisbon, Portugal in collaoration sixth Aduro Biotech.

 

Conformational Epitope Mapping by Cross-link Mass Spectrometry: Analysis of Ipilimumab, Nivolumab and Pembrolizumab





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