MegaTOF™ Megadalton MALDI Mass Spectrometer

Shimadzu and CovalX have partnered to offer an integrated MALDI solution for ultrahigh mass applications.

The MegaTOFTM has been developed by optimizing the integration of a high-performance Shimadzu linear MALDI TOF mass spectrometer with CovalX high-mass system, allowing outstanding detection of macromolecules up to 1500 kDa.

MegaTOFTM MALDI MS gives access to a broad range of applications, including direct analysis of protein-protein interactions such as complexes or biopharmaceutical aggregates. For these analyses, CovalX developed special cross-linking reagents and buffers for fast and specific stabilization of protein interactions. The reagents contain ‘cocktails’ of cross-linkers with different spacer lengths able to covalently bind specific protein complexes with a high degree of efficiency. The specificity facilitates the stabilization of covalent protein complexes – even in contaminated or unpurified samples.

The High-Mass MALDI applications are also available for the existing Shimadzu AXIMA MALDI (Assurance, Confidence, Performance) by retrofitting CovalX’s high-mass MALDI detection system on these instruments.

More information

Download supporting materials

Connect with CovalX

How can we help?

How did you hear about us?

Check this if you would like to enable CC to your email as verification of delivery. If any problem arises please contact us at