Pearl High Mass Detection System

A decade in development, CovalX is proud to announce our fourth generation in a series of High-Mass MALDI detection systems based on a unique conversion dynode technology. The CovalX HM4 and Pearl High-Mass systems enable unmatched detection of macromolecular ions into the MegaDalton range with nM sensitivity. The Pearl offers all the benefits in sensitivity and saturation you have come to trust from CovalX while keeping an emphasis on value. The HM4 system is the latest flagship reference for the detection of high molecular weight macromolecules. 

The Pearl High Mass Detection System

Due to popular demand, the CovalX Pearl High Mass Detection retrofit systems allows detection of high mass ions up to 1MDa at the lowest price point ever available. This detection system features the touchscreen controlled operation as featured on the latest equipment, allowing easy operation and control with any MALDI instrument.  Although this system allows detection of only positive ion detection, this is suitable for most common analysis, including most biotherapeutics and protein complexes.



Fourth Generation High-Mass Detector Retrofit Systems Comparison
  Pearl HM4
Full compatibility with any MALDI Instrument (Shimadzu, Bruker, ABSciex)
Wireless Touchscreen Control
Automated switching between High-Mass & Standard Detection
Detection of macromolecules and protein complexes up to 1 MDa
Positive Ion Detection
Detection of macromolecules and protein complexes to 2 MDa and above  
Negative Ion Detection  

See more about HM4 here

All High-Mass systems are available for every standard MALDI ToF mass spectrometers:

  • Applied Biosystems: 5800, 4800 and all previous models.
  • Bruker: UltrafleXtreme, Autoflex Speed and all previous models.
  • Shimadzu Kratos: Axima series.

No Change in Manufacturer Warranties and Services:

Installing a CovalX Pearl High-Mass System on your MALDI ToF mass spectrometer does not change any of the warranties or service contracts you may have with Bruker, ABSciex or Shimadzu.
CovalX's Pearl is controlled wirelessly using the CovalX's Android application. To switch between High-Mass detection and standard detection or between positive and negative ion detection modes, simply press a button on the touchscreen of your CovalX's Kindle controller.
CovalX Pearl High-Mass Systems does not change any of the previous features of your MALDI ToF instrument. After the retrofit, the standard detector in the linear mode is not removed. The operator can choose between high mass detection and normal detection in a few seconds simply by pressing a button on the touch screen of CovalX's Kindle controller.

With CovalX Pearl High-Mass Systems you can have access to the following applications:

Download supporting materials

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