Inventors
Barbara K. Felber, George N. Pavlakis, Sevasti KARALIOTA, Dimitrios STELLAS
Assignees
The United States Of America, As Represented By The Secretary, Department Of Health And Human Service
Abstract
This disclosure provides compositions and methods comprising combinations of IL-15 or an I L-15/IL-15Ra complex with one or more other active agents for the treatment of cancer. This disclosure also provides compositions and methods comprising combinations of IL-15 or an IL-15/I L-15Rct complex fused to IL-12 or a derivative thereof, and with one or more other active agents for the treatment of cancer. In some embodiments, the one or more active agents comprises an activator of PPAR. In some embodiments, the one or more active agents comprises inhibitor of FLT3. In some embodiments, the one or more active agents comprises a chemotherapeutic agent.
