Inventors
Carolyn R. Bertozzi, Muthukumar Ramanathan, Nicholas Till
Assignees
Leland Stanford Junior University
Abstract
Provided are soluble bispecific molecules. In some instances, the soluble bispecific molecules comprise a first moiety that specifically binds a cell surface molecule on a donor cell, and a second moiety that specifically binds a cell surface molecule on an acceptor cell. The soluble bispecific molecule comprises the first moiety stably associated with the second moiety and induces transfer of the cell surface molecule on the donor cell to the surface of the acceptor cell via trogocytosis. Compositions comprising the bispecific molecules and methods of using the bispecific molecules (e.g., for therapeutic and/or research purposes) are also provided.