Direct Mass Spectrometric Analysis of Aggregates of Therapeutic Protein



Alexis Nazabal and Ryan Jay Wenzel


  1. Covalx AG


The invention relates to a method of using high-mass matrix assisted laser desorption-ionization (MALDI) mass spectrometry for the quantitative analysis of the amount of aggregation (dimers, trimers or multimers) of antibodies or other therapeutic proteins in purified pharmaceutical samples or complex biological matrices, as well as to the use of this method for characterization of antibodies, drug development and quality control of therapeutic proteins, including automated high throughput applications.

CovalX Technology Referenced


Patent Number

US7943387 B2

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Categories : Patents, High-Mass MS