Direct Mass Spectrometric Analysis of Aggregates of Therapeutic Protein

text
May 17, 2011

Inventors

Alexis Nazabal and Ryan Jay Wenzel

Assignees

  1. Covalx AG

Abstract

The invention relates to a method of using high-mass matrix assisted laser desorption-ionization (MALDI) mass spectrometry for the quantitative analysis of the amount of aggregation (dimers, trimers or multimers) of antibodies or other therapeutic proteins in purified pharmaceutical samples or complex biological matrices, as well as to the use of this method for characterization of antibodies, drug development and quality control of therapeutic proteins, including automated high throughput applications.

CovalX Technology Referenced

MALDI-ToF

Patent Number

US7943387 B2

Contact our Scientific Team to Start the Conversation

Request A Call
Back
Categories : Patents, High-Mass MS
text
PREVIOUS : Does Chemical Cross-Linking with NHS Esters Reflect the Chemical Equilibrium of Protein-Protein Noncovalent Interactions in Solution?
NEXT : Monitoring Ligand Modulation of Protein-Protein Interactions by Chemical Cross-Linking And High-Mass MALDI Mass Spectrometry
text
CovalX
Powered by  GDPR Cookie Compliance
Privacy Overview

This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.