Direct Mass Spectrometric Analysis of Aggregates of Therapeutic Protein

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May 17, 2011

Inventors

Alexis Nazabal and Ryan Jay Wenzel

Assignees

  1. Covalx AG

Abstract

The invention relates to a method of using high-mass matrix assisted laser desorption-ionization (MALDI) mass spectrometry for the quantitative analysis of the amount of aggregation (dimers, trimers or multimers) of antibodies or other therapeutic proteins in purified pharmaceutical samples or complex biological matrices, as well as to the use of this method for characterization of antibodies, drug development and quality control of therapeutic proteins, including automated high throughput applications.

CovalX Technology Referenced

MALDI-ToF

Patent Number

US7943387 B2

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Categories : Patents, High-Mass MS
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