Mass Spectrometry of Large Complexes



Claudia Bich1, and Renato Zenobi1


  1. Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland


Mass spectrometry is becoming a more and more powerful tool for investigating protein complexes. Recent developments, based on different ionization techniques, electrospray, desorption/ionization and others are contributing to the usefulness of MS to describe the organization and structure of large non-covalent assemblies.

CovalX Technology Mentioned



The CovalX MALDI mass spectrometry high mass detection system allows for detection of ions up to the MDa range. It is based on a principle described by Bahr et al. and uses the formation of secondary ions upon collision with the large primary ions and then an electron multiplication stage.

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Categories : High-Mass MS, HM5