Claudia Bich1, and Renato Zenobi1
- Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland
Mass spectrometry is becoming a more and more powerful tool for investigating protein complexes. Recent developments, based on different ionization techniques, electrospray, desorption/ionization and others are contributing to the usefulness of MS to describe the organization and structure of large non-covalent assemblies.
CovalX Technology Mentioned
The CovalX MALDI mass spectrometry high mass detection system allows for detection of ions up to the MDa range. It is based on a principle described by Bahr et al. and uses the formation of secondary ions upon collision with the large primary ions and then an electron multiplication stage.