Novel Antibodies to a gamma variable 4 (Vγ4) chain of a γδ T cell receptor (TCR)

Inventors

RobOxana Polyakova, Oliver Nussbaumer, Adrian Hayday, Pierre Vantourout,

Assignees

1. Gammadelta Therapeutics Limited (WestWorks 195 Wood Lane White City Place London W12 7FQ, GB)

Abstract

An isolated antibody or fragment thereof, which specifically binds to a gamma variable 4 (Vγ4) chain of a γδ T cell receptor (TCR) and not to a gamma variable 2 (Vγ2) chain of a γδ TCR is provided herein. Methods of treatment and other uses of said antibodies are also provided along with methods of producing said antibodies.

CovalX Technology Used

Epitope Mapping
XL-MS

https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2021171002