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CovalX Crosslinking Kits
Because of the tendency of these complexes to dissociate during analysis, the analysis of protein complexes by mass spectrometry is typically labor intensive. CovalX has developed a method for the easy and fast analysis of protein complexes using High-Mass MALDI mass spectrometry coupled with chemical crosslinking. The first step of the analysis is to stabilize the noncovalent complexes of interest using the CovalX dedicated cross-linking reagents and protocols. After stabilization, the sample is ready for direct analysis by High-Mass ToF mass spectrometry.
To effectively analyze intact protein complexes by High-Mass MALDI ToF mass spectrometry, it is crucial to stabilize specifically the complexes with highly efficient cross-linking reagents. CovalX has developed dedicated reagent and buffers to prepare non-covalent protein complexes for High-Mass MALDI analysis. To increase cross-linking efficiency, CovalX’s reagents contain cocktails of cross-linkers with different spacer lengths able to covalently bind specific protein complexes with the highest efficiency. The specificity of CovalX cross-linking reagents allows you to covalently stabilize linked protein complexes even in contaminated or unpurified samples.
MALDI MS Analysis Kits and Reagents for Protein Interactions:
|MALDI MS Analysis Kits and Reagents||Mass Range||Part No.|
|K50 MALDI MS Analysis Kit||0-50 kDa||W2010k50|
|K100 MALDI MS Analysis Kit||20-100 kDa||W2010k100|
|K200 MALDI MS Analysis Kit||100-1000 kDa||W2010k200|
|R50 Stabilizer Reagent||0-50 kDa||W2010R50|
|R100 Stabilizer Reagent||20-100 kDa||W2010R100|
|R200 Stabilizer Reagent||100-1000 kDa||W2010R200|
To learn more or order our crosslinking kits
Contact Us, Email us at email@example.com, call us at +1(617) 297 2263