CovalX HM5
CovalX HM5

Crosslinking Kits

Talk to Our Scientists

"*" indicates required fields

This field is for validation purposes and should be left unchanged.

CovalX Crosslinking Kits

Because of the tendency of these complexes to dissociate during analysis, the analysis of protein complexes by mass spectrometry is typically labor intensive. CovalX has developed a method for the easy and fast analysis of protein complexes using High-Mass MALDI mass spectrometry coupled with chemical crosslinking. The first step of the analysis is to stabilize the noncovalent complexes of interest using the CovalX dedicated cross-linking reagents and protocols. After stabilization, the sample is ready for direct analysis by High-Mass ToF mass spectrometry.

To effectively analyze intact protein complexes by High-Mass MALDI ToF mass spectrometry, it is crucial to stabilize specifically the complexes with highly efficient cross-linking reagents. CovalX has developed dedicated reagent and buffers to prepare non-covalent protein complexes for High-Mass MALDI analysis. To increase cross-linking efficiency, CovalX’s reagents contain cocktails of cross-linkers with different spacer lengths able to covalently bind specific protein complexes with the highest efficiency. The specificity of CovalX cross-linking reagents allows you to covalently stabilize linked protein complexes even in contaminated or unpurified samples.

MALDI MS Analysis Kits and Reagents for Protein Interactions:

MALDI MS Analysis Kits and Reagents Mass Range Part No.
K50 MALDI MS Analysis Kit 0-50 kDa W2010k50
K100 MALDI MS Analysis Kit 20-100 kDa W2010k100
K200 MALDI MS Analysis Kit 100-1000 kDa W2010k200
R50 Stabilizer Reagent 0-50 kDa W2010R50
R100 Stabilizer Reagent 20-100 kDa W2010R100
R200 Stabilizer Reagent 100-1000 kDa W2010R200
Talk to Our Scientists

Our team is available to answer any of your questions about our products and services