CovalX HM5
CovalX HM5

HM5 Pearl High-Mass Detection System

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CovalX HM5 Pearl High-Mass Detection System

A decade in development, CovalX is proud to announce our fifth generation in a series of High-Mass MALDI detection systems based on a unique conversion dynode technology. The CovalX HM5 and HM5 Pearl High-Mass systems enable unmatched detection of macromolecular ions into the MegaDalton range with nM sensitivity. The HM5 Pearl offers all the benefits in sensitivity and saturation you have come to trust from CovalX while keeping an emphasis on value. The HM5 system is the latest flagship reference for the detection of high molecular weight macromolecules.

The HM5 Pearl High Mass Detection System

Due to popular demand, the CovalX HM5 Pearl High-Mass Detection retrofit systems allow detection of high-mass ions up to 1MDa at the lowest price point ever available.

This detection system features an integrated software control directly on the PC controlling allowing easy operation and control with any MALDI instrument. Although this system allows detection of only positive ion detection, this is suitable for most common analysis, including most biotherapeutics and protein complexes.

Fifth Generation High-Mass Detector Retrofit Systems Comparison HM5 Pearl HM5
Full compatibility with any MALDI Instrument (Shimadzu, Bruker, ABSciex)
Integrated Software Control
Automated switching between High-Mass & Standard Detection
Detection of macromolecules and protein complexes up to 1 MDa
Positive Ion Detection
Detection of macromolecules and protein complexes to 2 MDa and above
Negative Ion Detection

HM5 backpage diagram

All High-Mass systems are available for every standard MALDI ToF mass spectrometers:

  • Bruker: UltrafleXtreme, Autoflex Speed and all previous models.
  • Shimadzu Kratos: Axima series.
  • Applied Biosystems: 5800, 4800 and all previous models.

No Change in Manufacturer Warranties and Services

  • Installing a CovalX HM5 Pearl High-Mass System on your MALDI ToF mass spectrometer does not change any of the warranties or service contracts you may have with Bruker, ABSciex or Shimadzu.
  • CovalX’s HM5 Pearl is directly using CovalX’s web application. To switch between High-Mass detection and standard detection or between positive and negative ion detection modes, simply press a button on the software on the same PC that controls your instrument.
  • CovalX HM5 Pearl High-Mass Systems does not change any of the previous features of your MALDI ToF instrument. After the retrofit, the standard detector in the linear mode is not removed. The operator can choose between high mass detection and normal detection in a few seconds simply by pressing a button on the CovalX’s software.

With CovalX HM5 Pearl High-Mass Systems you can have access to the following applications

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Our team is available to answer any of your questions about our products and services