Inventors
Pawel Stocki, Krzysztof Bartlomiej Wicher, Jaroslaw Michal Szary, Julia Lynn Rutkowski
Assignees
Ossianix Inc
Abstract
The present invention relates to the fields of molecular medicine and targeted delivery of therapeutic or diagnostic agents to cells outside the vascular system and into the parenchymal tissue of organs within the body. More specifically, the present invention relates to improved TfR-binding moieties based on shark VNARs capable of crossing the blood brain barrier (BBB) and capable of carrying and releasing cargo specifically targeted to the parenchymal tissue of the brain.