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Temporal Activation of WNT/β-Catenin Signaling is Sufficient to Inhibit SOX10 Expression and Block Melanoma Growth

Authors Rexhep Uka1, Christian Britschgi1, Anja Krättli1, Claudia Matter1, Daniela Mihic2, Michal J. Okoniewski3, Marco Gualandi1, Roger Stupp1, Paolo ...

Targeting Glycosylated PD-1 Induces Potent Anti-Tumor Immunity

Authors Linlin Sun1, Chia-Wei Li2, Ezra M. Chung3, Riyao Yang4, Yong-Soo Kim5, Andrew H. Park5, Yun-Ju Lai6, Yi Yang4, Yu-Han ...

Superstructure Formation by RodZ Hexamers of Shigella Sonnei Maintains the Rod Shape of Bacilli

Authors Jiro Mitobe1, Fumiko Nishiumi2, Itaru Yanagihara2, Shouji Yamamoto1, Makoto Ohnishi1 Organizations Department of Bacteriology I, National Institute of Infectious ...

Crystal and Cryo-EM Structures of the Cytosolic G Protein Alpha Chaperone and Guanine Nucleotide Exchange Factor Ric-8A Bound to Gαi1

Authors Levi J. McClelland1, Kaiming Zhang2, Tung-Chung Mou3, Jake Johnston3, Cindee Yates-Hansen1, Shanshan Li2, Celestine J. Thomas1, Tzanko I. Doukov4, ...

The Plasma Factor XIII Heterotetrameric Complex Structure: Unexpected Unequal Pairing Within a Symmetric Complex

Authors Sneha Singh1, Alexis Nazabal2, Senthilvelrajan Kaniyappan3, Jean-Luc Pellequer4, Alisa S. Wolberg5, Diana Imhof6, Johannes Oldenburg1, Arijit Biswas1 Organizations Institute ...

In Vitro Skin Penetration of Dendrimer Nanoparticles

Authors Margaret E.K. Kraeling1, Vanessa D. Topping1, Kathleen R. Belgrave1, Kristian Schlick2, Eric Simanek2, Sonny Man3, Sureshbabu Dadiboyena4,5, Anil ...

Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye

Authors Whitney Shatz1, Philip E. Hass1, Nikhil Peer1, Maciej T. Paluch1, Craig Blanchette 1, Guanghui Han2, Wendy Sandoval2, Ashley Morando3, Kelly ...

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